VIVOX

ACCELERATING DRUG DISCOVERY

BY BRIDGING THE GAP BETWEEN IDEA

AND MEDICINE IN VIVO

Welcome To Vivox

We supply professional pre-clinical services, designed and performed by our team of experts

Vivox is dedicated to support and promote medical oriented companies to cross their pre-clinical stages for successful FDA, IND application, we are honored to share our pre-clinical services and knowledge both in-vivo and in-vitro with our clients in order to advance potential new therapies towards clinical stages and beyond

Why Vivox

Personalized service

Personalized service

Our team of experts will walk you through all the stages, from planning to results

Excellency

Excellency

excellency is our goal and form in every step we make

Reliability

Reliability

With years of experience, our team can do any work required with the highest reliability

Customized research

Customized research

Including our in-vitro and in-vivo departments

Research Services

In Vivo

We work with genetically modified and diseased induced rodent models,
evaluating substances and medical device affects by daily monitoring and examination.
We adjust with our clients the dosage, method of treatment and experiment critical points.

Metabolic Diseases

Metabolic Diseases

  • Obesity models:
    Expressed in high fat levels and high glucose in serum
  • 60% – induced by high fat diet food intake
  • DB/ DB –
    Induced by genetic defection for leptin receptor.
    (Diabetes type II)
  • STZ – to induce Diabetes type I
  • Glucose Tolerance Tests

Degenerative Diseases

Degenerative Diseases

  • Parkinson’s disease – Induced by 6-hydroxydopamine
    (6-OHDA) or by MPTP administration
  • Schizophrenia disease – LI model for negative symptoms
  • Spinal cord injury
  • Amyotrophic Lateral Sclerosis (ALS) –
    Induced by genetic defection
    on sod-1 gene for Amyotrophic
    lateral sclerosis disease
  • Stroke – via Jugular vain model

Immunological Models

Immunological Models

  • EAE – Experimental Autoimmune Encephalitis Induce by MOG emulsion for Multiple Sclerosis
  • DTH – Delayed Type Hypersensitivity for Anti or Pro inflammatory activity’s
  • IBD- Inflammatory bowel disease
    DSS – to induce Colitis
    TNBS – Crohn’s disease model
  • Psoriasis – for chronic skin condition
  • CLP – Cecal Ligation Puncture for Sepsis disease

Special Surgical Expertise

Special Surgical Expertise

  • Brain – CSF extraction, brain IVC, Cisterna magna injection
  • Peritoneum manipulations – Catheter implantations and internal organ manipulations
  • Facial vain post-natal day 1 in mice
  • Intratracheal administration – mimic asthma disease

Oncological Models

Oncological Models

  • PDX implantation
  • Brain injection of tumour cells
  • Intra- Peritoneum implantation of all cells lines in internal organs, (E.g. liver, kidney)
  • Tumour cell injections for metastatic evaluation
  • S.C tumour injection

General Models

General Models

  • Pharmacokinetics (PK)
  • Pharmacodynamics (PD)
  • Toxicity
  • Maximum Tolerated Dose (MTD)
  • Absorption, Distribution, Metabolism, and Excretion (ADME)
  • MI model – Myocardial Infraction
  • Sciatic nerve regeneration

In Vitro

With our brand new equipment, we provide an advanced in vitro lab services that complete our in vivo services.
Here part of the in vitro lab service variety we supply:

Cell Culture

Cell Culture

  • Cancer Cell Lines
  • Primary Cells
  • Stem Cells
  • Cell Therapy

Ex Vivo Studies

Ex Vivo Studies

  • Transient and Stable Transfection
  • Cell Viability
  • Cell Proliferation
  • Various Difrentiation Assays

Molecular Biology

Molecular Biology

  • Cytokines and cellular markers measurements
  • Analysis of:
    – DNA
    – RNA
    – Protein
  • Safety: Cytotoxicity Assays – Cell Viability Assays

Analytics

Analytics

  • PDX implantation
  • Fluorescent-Activated Cell Storing Analysis (FACS)
  • Quantitative Polymerase Chain Reaction (PCR)
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Statistics

Our Team

Omer Miller, Ph.D

Received PhD in Neuro-Immunology from the Weizmann institute of science. During his PhD, he conducted numerous experiments elucidating the role of the blood cerebrospinal fluid barrier as a phenotype-educative gate for beneficial M2 macrophages in the model of spinal cord injury (SCI). During his studies, Omer mastered several in-vivo mice models including transient and permanent middle cerebral artery occlusion (MCAO), SCI, splenectomy and autoimmune uveitis. Also, Omer developed and mastered a unique in-vivo procedure to aspire clean cerebrospinal fluid (CSF) from mice. Since he graduated, Omer served as the CTO of a leading pre-cro company aka Science in action LTD. He designed and executed tremendous amount of experiments to support companies from early stages of pre-clinical work to the demonstration of proof of concept in the relevant animal models. Omer gained vast expertise in various in-vivo animal models as well as complicated microsurgeries.

Ely Elbaz, M.A

Ely received his MA in Psycho–Biology from the Tel – Aviv University in Israel. During his studies, Ely focused on Neuro-Immune Communication mediated via physiological stress response. He examined these effects on cancer metastatic process. Since he completed his studies, Ely joined a leading preclinical research company in Israel as a study director and a scientist. As part of his job, Ely specialized in protocols design and writing for efficacy experiments. He worked in close contact with the health department to ensure and approve the studies. Over the last seven years, Ely expertise in developing, designing and conducting several animal models to mimic  human diseases and syndromes like Parkinson, Cancer, Diabetic, Coagulation disorders, Intratracheal Autoimmune conditions and more.

Haviva Nodelman, M.Sc

Haviva received her M.Sc. in biology from the University of Haifa. Mrs. Nodelman has over 9 years in the Biotechnology industry. Before joining Vivox, she worked as a QC analyst for 5 years in Protalix (FDA approval) and gained great knowledge and skills working in a GMP environment. Haviva brings to VIVOX a wide experience in molecular biology, biochemistry, Immunology, Cell culture and microbiological methods, as well as experience in method development and validations.

Collaborative Ecosystem

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