General Models

Vivox’s experts conduct a series of tests and experiments to determine specific metrics of drugs performance on the following aspects: 

  • Pharmacokinetics (PK)
  • Pharmacodynamics (PD)
  • Toxicity
  • Maximum Tolerated Dose (MTD)
  • MI model – Myocardial Infraction
  • Sciatic nerve regeneration

 

We provide holistic and efficient in vivo assay services for our customers with special technology platforms and professional staff. As world-leading experts, our scientists perform all aspects of a product’s potency to make the whole process as quickly and cost-effectively possible.

Sciatic nerve regeneration

Static nerve regeneration
Locomotion and posture are based on muscular actions controlled by the nervous system. Once the peripheral nervous system (PNS) is damaged, the control of the movement is affected, and injuries,...

MI model – Myocardial Infraction

MI model_Myocardial Infraction
Myocardial infarction (MI) is a disease that causes irreversible damage to the heart. The lack of available infarcted tissue limits research of human myocardial infarction, and for that reason, animal...

Maximum Tolerated Dose (MTD)

Maximum Tolerated dose
An essential part of preclinical drug development is to define the dose and schedule for it. Before conducting in vivo PK studies to determine the dosing schedule, the dose has...

Toxicity

Toxicity
A toxicity test is designed to generate data concerning the adverse effects of a substance on human or animal health. The primary objective of toxicology studies in the drug discovery...

Pharmacodynamics (P.D.)

Pharmacodynamics
Pharmacodynamics is the study of the biochemical, physiologic, and molecular effects of drugs on the body and involves receptor binding (including receptor sensitivity), post-receptor effects, and chemical interactions. In other...

Pharmacokinetics (P.K.)

Pharmacokinetics
Pharmacokinetics is the study of the dynamic movements of xenobiotics (foreign chemicals) during their passage through the body. It includes the kinetics of absorption, distribution, biotransformation/metabolism, and excretion. Drug activity...
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