Cancer Models and Oncology Research
Cancer research is a rapidly evolving field, and rodent models have been instrumental in advancing our understanding of oncogenesis and developing antineoplastic treatments. To bridge the physiological differences across species, humanized mouse models have been developed that maintain the advantages of rodent research with the necessary human elements.
Vivox offers a wide panel of CRO services, in vivo and in vitro, allowing researchers valuable insights into the complexities of cancer biology. Our humanized rodent models provide a dynamic platform for investigating tumor growth dynamics, metastatic profiling, and treatment response in living organisms. With advanced imaging technologies such as IVIS (In Vivo Imaging System), we enable real-time monitoring of tumor progression and biodistribution, paving the way for personalized cancer treatments. Our in vitro oncological models enable researchers to explore the molecular mechanisms that drive cancer development and progression. By using engineered cell lines and sophisticated culture systems, we recreate the tumor microenvironment and study cellular interactions, drug responses, and genetic alterations with unparalleled precision.
At Vivox, we combine the strengths of in vivo and in vitro expertise, to facilitate comprehensive investigations from bench to bedside. Our multidisciplinary team of experts collaborates to design customized experiments and accelerate innovative oncological discoveries. Join us in revolutionizing cancer research and shaping the future of precision medicine.
The following cancer models for drug candidates and oncology research are available at Vivox:
Our services support a variety of therapeutic areas
Microbiome
Cell & Gene based Therapy
Biological therapy
Cannabis based therapy
Pharmaceuticals
Nutraceuticals
Medical devices
Oncological Models
Unique microsurgical techniques for orthotopic tumor inoculation:
• Intrahepatic tumor cell inoculation
• Subcapsular renal inoculation
• Intrapancreatic tumor cell microinjection
• Urinary bladder inoculation
• Lung tumor inoculation
• Colorectal tumor cell inoculation
• Ovarian cancer cell inoculation
Metastatic Cancer Models – Optimization and Dynamic Progression Monitoring
Optimizing metastatic cancer models and dynamically monitoring disease progression are crucial aspects of preclinical oncological research. Vivox excels in refining metastatic cancer models to accurately mimic human disease, incorporating factors like tumor microenvironment, immune interactions, and metastatic cascade components. Vivox’s expertise lies in developing advanced techniques for real-time monitoring of metastatic progression, utilizing imaging modalities such as bioluminescence, fluorescence, and MRI. This dynamic monitoring enables precise assessment of metastatic spread, therapeutic responses, and disease dynamics over time, facilitating the discovery of novel treatments and personalized medicine strategies for metastatic cancers.
Cancer cell lines
Vivox specializes in both in-vivo and in-vitro cancer models, leveraging advanced technologies and expertise to provide comprehensive capabilities for cancer research. Through collaboration with researchers and clinicians, Vivox contributes to advancing our understanding of cancer biology, identifying novel therapeutic targets, and developing personalized treatment approaches to improve patient outcomes.
Primary cell
Primary cells are directly isolated from living organisms, such as humans or animals, and then cultured in-vitro for research purposes. Unlike cell lines, which are immortalized and can divide indefinitely, primary cells have a limited lifespan and retain characteristics similar to cells in their natural environment.
Vivox specializes in working with primary cells, offering expertise in cell isolation, culture techniques, and functional assays. By utilizing primary cells in research, Vivox contributes to advancing knowledge in areas such as cancer biology, immunology, regenerative medicine, and drug discovery.
Stem cells
Stem cells are a remarkable type of cell with the unique ability to differentiate into various specialized cell types in the body. Stem cells play a crucial role in embryonic development, tissue repair, and regeneration. Stem cells can be broadly categorized into embryonic stem cells (ESCs) derived from embryos, and adult stem cells found in various tissues such as bone marrow, adipose tissue, and the brain. Due to their regenerative potential, stem cells hold great promise in regenerative medicine, tissue engineering, and disease modeling.
Vivox specializes in stem cell research, including the study of stem cell biology, differentiation pathways, and the development of stem cell-based therapies for various medical conditions. Our expertise in stem cell technology contributes to advancements in understanding cell biology, disease mechanisms, and innovative therapeutic approaches in regenerative medicine.
IVIS: in vivo imaging and analytical support
Luciferase & fluorescent cells
Research outcomes - examples
